G Protein-Coupled Receptors  LIBRARY

PRESTWICK GPCR DRUG LIBRARY

A collection of 265 approved drugs

G protein-coupled receptors (GPCRs) are the most successful targets in pharma and approximately 40% of approved drugs interact with this family. Among the 800 GPCRs described more than 140 orphan GPCRs are functionally unknown and their endogenous ligands remain unidentified. Prestwick GPCR Drug Library is a collection of 265 approved drugs known to interact primarily with a GPCR. The use of this GPCR library may allow characterization of orphan GPCRs (deorphanization), facilitate pharmacology research and drug innovation.


PRESTWICK CHEMICAL Key features

    PRESTWICK CHEMICAL A unique collection of 265 small molecules approved drugs (FDA, EMA and other agencies)
    PRESTWICK CHEMICAL High degree of chemical and pharmacological diversity
    PRESTWICK CHEMICAL A constant quality control ensures high purity and stable compounds

Target distribution
Therapeutic class

PRESTWICK CHEMICALApplication

    PRESTWICK CHEMICAL Deorphanization
    PRESTWICK CHEMICAL Repurposing
    PRESTWICK CHEMICAL Assay validation

PRESTWICK CHEMICALHow provided?

    PRESTWICK CHEMICAL Pre-dissolved in DMSO ready for screening at precise 10 mM concentration and tailored volumes (100 ┬ÁL to 1 mL) in 96 or 384 well plates, and customizable (volumes, plating)
    PRESTWICK CHEMICAL As dry powder in vials starting from 10 mg, with cherry-picking possibility

PRESTWICK CHEMICALA database ready for use

    PRESTWICK CHEMICAL Always provided with a highly annotated database as structural data file (SDF), IsisBase (DB) as well as an XLS file. Annotation includes target, therapeutic class/effect, side effects, patent and AMDET information
    PRESTWICK CHEMICAL A file containing names and structures may be obtained on request prior purchasing
    PRESTWICK CHEMICAL Additional amounts of substances: Re-supply of any hit-compound up to 100 mg provided



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This chemical screening library is sold with
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