PRESTWICK GPCR DRUG LIBRARY

A set of approved drugs known to interact with a GPCR

G protein-coupled receptors (GPCRs) are the most successful targets in pharma and approximately 40% of approved drugs interact with this family. Among the 800 GPCRs described more than 140 orphan GPCRs are functionally unknown and their endogenous ligands remain unidentified. Prestwick GPCR Drug Library is a collection of 265 approved drugs known to interact primarily with a GPCR. The use of this GPCR library may allow characterization of orphan GPCRs (deorphanization) and facilitate pharmacology research and drug innovation.



PRESTWICK CHEMICAL Key features

    PRESTWICK CHEMICAL A unique collection of 265 small molecules approved drugs (FDA, EMA and other agencies)
    PRESTWICK CHEMICAL High degree of chemical and pharmacological diversity
    PRESTWICK CHEMICAL A constant quality control ensures high purity and stable compounds - Mean MW: 320

Target type distribution
Therapeutic class distribution

PRESTWICK CHEMICALApplication

    PRESTWICK CHEMICAL Deorphanization
    PRESTWICK CHEMICAL Repurposing
    PRESTWICK CHEMICAL Assay validation

PRESTWICK CHEMICALHow provided?

    PRESTWICK CHEMICAL Pre-dissolved in DMSO ready for screening at precise 10 mM concentration and tailored volumes (100 ┬ÁL to 1 mL) in 96 or 384 well plates, and customizable (volumes, plating)
    PRESTWICK CHEMICAL As dry powder in vials starting from 10 mg, with cherry-picking possibility

PRESTWICK CHEMICALA database ready for use

    PRESTWICK CHEMICAL Always provided with a highly annotated database as structural data file (SDF), IsisBase (DB) as well as an XLS file. Annotation includes target, therapeutic class/effect, side effects, patent and AMDET information
    PRESTWICK CHEMICAL A file containing names and structures may be obtained on request prior purchasing
    PRESTWICK CHEMICAL Additional amounts of substances: Re-supply of any hit-compound up to 100 mg provided


This chemical screening library is sold with
"no strings attached"