PRESTWICK PEPTIDIC MACROCYCLE LIBRARY

PRESTWICK PEPTIDIC MACROCYCLE LIBRARY

A Unique Library of 400 Peptidic Macrocycles

Prestwick and GENEPEP propose a library of high purity 400 short macrocyclic peptides designed with a mix of natural and non-natural amino acids and different types of cyclization (disulfide, lactam, triazole). Macrocyclization can provide a method of improving target potency and modulating selectivity. Cyclic peptides in comparison to their linear counterparts combine multiple interesting properties like low toxicity and improved enzymatic stability.




PRESTWICK CHEMICAL Key features

    PRESTWICK CHEMICAL A collection of 400 short (5 amino acids), chemically synthesized peptidic macrocycles containing natural and non-natural amino acids
    PRESTWICK CHEMICAL 17 or 20-membered ring
    PRESTWICK CHEMICAL Different cyclization motifs (disulfide, lactam, triazole)
    PRESTWICK CHEMICAL Constrained, stabilized peptide sequences with exposed side chains
    PRESTWICK CHEMICAL Conveniently prepared, ready for multiple screenings


PRESTWICK CHEMICALApplication

    The Prestwick Peptidic Macrocycle Library is a great starting point to identify enzyme inhibitors, agonist or antagonists of GPCRs, protein-protein interaction disruptors (inhibitors).


PRESTWICK CHEMICALHow Provided?

    PRESTWICK CHEMICAL Lyophilized in five 96-well plates. The amount of compound in each well is 0.1 µmol and yields a 1 mM peptidic macrocycle solution when adding 100 µL of solvent
    PRESTWICK CHEMICAL Powder form on request







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This chemical screening library is sold with
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