PRESTWICK ORIGINAL MOLECULES LIBRARY

Prestwick Original molecules

Your Premium Resource For Novel Screening Hits

A collection of 344 innovative screening compounds, based on a series of carefully selected new original scaffolds. All molecules have been designed to ensure optimal diversity, and are suitable for diverse chemical modification yielding analogs with promising IP positions. The library combines potential high therapeutic score with favorable drug-like and ADME-Tox properties.



PRESTWICK CHEMICAL Distribution of MW and clogP:

    The Prestwick Original Molecules library contains innovative compounds with favorable lead-like (Oprea) and drug-like (Lipinski) properties.



PRESTWICK CHEMICAL Predicted targets for each compound:

    Using a structure-based approach (pharmacophore-based virtual screening), each compound was investigated for its potential interactions with protein targets ranging from CNS to oncology, cardiovascular and antimicrobial fields. Target prediction allows to claim that the selected Prestwick Original Molecules (POM) might be active in different therapeutic areas.

PRESTWICK CHEMICALHow provided?

    Two different presentations:

      PRESTWICK CHEMICAL pre-dissolved in DMSO ready for screening at precise 10 mM concentration and tailored volumes (100 ┬ÁL to 1 mL) in 96 or 384 well plates, and customizable (volumes, plating).
      PRESTWICK CHEMICAL as dry powder in vials starting at 10 mg, with cherry-picking possibility.

PRESTWICK CHEMICALA database ready for use:

    The database is supplied in three formats (SDF, DB, XLS)



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