Prestwick Chemical Library®

A Recognized Smart Chemical Screening Library

Drugs for the Prestwick Chemical Library
A unique collection of 1280 small molecules, mostly approved drugs (FDA, EMA and other agencies) selected by a team of medicinal chemists and pharmacists for their high chemical and pharmacological diversity as well as for their known bioavailability and safety in humans.
Designed to increase the potential of getting "high-quality" hits, our chemical screening library is a valuable tool to accelerate lead discovery (see success stories).
Over the 16 past years, “hit-likeness” and “hit-workability” of our smart chemical library have been substantially reported by users  in > 350 publications.

More features of the Prestwick Chemical Library® are detailed in posters presented regularly at international meetings :

  • The Prestwick Chemical Libary®, a valuable tool for screening (pdf)
  • Pharmacophore-based characterization of The Prestwick Chemical Library® (pdf)
  • Screening for neuroprotective activity in a Drosophila model of Parkinson’s disease using a new Prestwick Drosophila Library (pdf)
  • High throughput behavorial sleep assay for larval zebrafish (pdf)

How provided?

Two different presentations:

  • Pre-dissolved in DMSO ready for screening at precise 10 mM concentration and tailored volumes (100 µL to 1 mL) in 96 or 384 well plates, and customizable (volumes, plating)
  • As dry powder in vials starting at 10 mg, with cherry-picking possibility
A regular quality control ensures high purity compounds.

A database ready for use:

  • A database extensively annotated by a pharmacist and updated regularly is provided as structural data file (SDF), IsisBase (DB) as well as XLS file. Annotation includes literature references, target, therapeutic class/effect, side effects, and AMDET information, (see Baclofen example)
  • Personalized database can also be available upon request
  • A file containing names and structures may be required on request prior purchasing

Additional amounts of substances:

Re-supply of any hit-compound up to 100 mg provided at a small fee.
The Prestwick Chemical Library is sold with "no strings attached" (i.e. no royalties or milestones are requested).