Medicinal Chemistry Services

MedChem projects

Hit to Lead

Prestwick Chemical provides high-quality medicinal chemistry services for hit to lead and lead optimization programs. Our medicinal chemistry experts help selecting in a multidisciplinary environment the most promising scaffolds for progression into lead optimization.

    PRESTWICK CHEMICAL Multiparameter optimization of one selected hit series (e.g. activity, selectivity, early ADME profile)
    PRESTWICK CHEMICAL Dedicated team of one senior PhD and one experienced associate (extra FTE on request)
    PRESTWICK CHEMICAL Iterative cycles including design, synthesis, screening testing and activity analysis
    PRESTWICK CHEMICAL IP landscape will be considered for the design
    PRESTWICK CHEMICAL Strong and frequent communication

Lead optimization

Starting from a validated lead, our medicinal chemists initiate the optimization process in order to provide a suitable compound for pre-clinical phase.
The research strategy implies iterative cycles of design and assessment.

    PRESTWICK CHEMICAL Multiparameter optimization of one selected lead: activity, efficacy, selectivity, ADME-Tox and PK
    PRESTWICK CHEMICAL Dedicated team of one senior PhD and one experienced associate (extra FTE on request)
    PRESTWICK CHEMICAL Iterative cycles including design, synthesis, screening testing and activity analysis
    PRESTWICK CHEMICAL IP landscape will be considered for the design
    PRESTWICK CHEMICAL Strong and frequent communication
Hit to Lead

request a quote

Lead optimization

request a quote

Medchem project options:

Hit to lead and lead optimization programs are proposed through three different packages based on FTE model collaboration:

ESSENTIAL
Package
PREMIUM
Package
FULL PREMIUM
Package
Chemistry

Chemical syntheses including starting materials, reagents, solvents, purification, analytical characterization (QC), progress report (bi-monthly), experimental procedures, TC, compounds shipping. Exploratory chemistry and focused libraries

MedChem Design

Iterative cycles including design, synthesis and activity analysis. Design of IP free derivatives, scaffold hopping, patent busting. Multi-parameter analysis and optimization

CADD

Pharmacophore-based virtual screening (hit finding, scaffold hopping), Docking (SAR, binding mode analysis), in silico profiling (off-targets activity), ADME and physicochemical property prediction, data mining

ADME-PK

Key ADME parameters (ex: microsomal stability, permeability, solubility, PK) available and included for a set of compounds.





sign up to our
NEWSLETTER:



40
PROJECTS

10 compounds
IN CLINICAL PHASE

1 COMPOUND
ON THE MARKET

650 Clients
FOR THE LIBRARIES

Do you want more informations?